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1. Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge

   BioXFEL Publications 4 Feb 2021 Contributor(s): James Fraser

   http://dx.doi.org/10.1038/s41592-020-01051-w AbstractThis paper describes outcomes of the 2019 Cryo-EM Model Challenge. The goals were to (1) assess the quality of models that can be produced from cryogenic electron microscopy (cryo-EM) maps using current modeling software, (2) evaluate reproducibility of modeling results from different software…

   https://bioxfel.org/resources/1972

2. Jobs at Lawrence Berkeley National Laboratory

   Opportunities 8 Sep 2021

   Two new positions are available in the group of Aaron Brewster at Lawrence Berkeley National Laboratory. Computational Project Scientist - https://lbl.taleo.net/careersection/2/jobdetail.ftl?job=93507 Computational Postdoctoral Scholar - https://lbl.taleo.net/careersection/2/jobdetail.ftl?job=93506 In these exciting roles, you will work in…

   https://bioxfel.org/content/article/433

3. A SAXS-based approach to rationally evaluate radical scavengers – toward eliminating radiation damage in solution and crystallographic studies

   BioXFEL Publications 10 Aug 2021 Contributor(s): Edward Snell

   http://dx.doi.org/10.1107/s1600577521004045 X-ray-based techniques are a powerful tool in structural biology but the radiation-induced chemistry that results can be detrimental and may mask an accurate structural understanding. In the crystallographic case, cryocooling has been employed as a successful mitigation strategy but also has its…

   https://bioxfel.org/resources/2068

4. Interviewing Skills Workshop

   Events 1 Feb 2021

   Feb 01 2021

   Workshop 2: Monday, February 1, 2021

   https://bioxfel.org/events/details/1248

5. Graduated BioXFEL Summer Interns

   Education 18 Oct 2016

   BioXFEL is committed to ensuring a quality experience for all interns both during and after their internships. We frequently follow up with interns after they have graduated, track their progression through their scientific careers and provide extended support. Some interns choose to reapply to BioXFEL for a second summer, while others move to…

   https://bioxfel.org/content/article/180

6. Call for Papers on "Novel Structural Studies of Coronavirus Proteins"

   News 26 Mar 2021

   This Special Issue, “Novel Structural Studies of Coronavirus Proteins”, will gather both research and review articles from experts in the field with the ultimate goal of creating an international platform that provides with rich and reference information on the latest advances and exciting discoveries in the field of X-ray…

   https://bioxfel.org/content/article/422

7. A user-friendly plug-and-play cyclic olefin copolymer-based microfluidic chip for room-temperature, fixed-target serial crystallography

   BioXFEL Publications 25 Sep 2023 Contributor(s): Kevin Gu, Megan Shelby, Sankar Raju Narayanasamy, Sabine Botha, Christopher Kupitz, Matthew Coleman, Matthias Frank

   http://dx.doi.org/10.1107/s2059798323007027 Over the past two decades, serial X-ray crystallography has enabled the structure determination of a wide range of proteins. With the advent of X-ray free-electron lasers (XFELs), ever-smaller crystals have yielded high-resolution diffraction and structure determination. A crucial need to continue…

   https://bioxfel.org/resources/2195

8. Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

   BioXFEL Publications 14 Apr 2021 Contributor(s): Iris Diane Young, James Holton, Michael Thompson, James Fraser, Ron Morganti

   http://dx.doi.org/10.1126/sciadv.abf8711 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate–ribosylation signaling. This enzyme is a promising antiviral target because catalytic mutations render viruses nonpathogenic. Here, we…

   https://bioxfel.org/resources/2046

9. Biological Networks across Scales—The Theoretical and Empirical Foundations for Time-Varying Complex Networks that Connect Structure and Function across Levels of Biological Organization

   BioXFEL Publications 21 May 2021 Contributor(s): Edward Snell

   http://dx.doi.org/10.1093/icb/icab069 Abstract Many biological systems across scales of size and complexity exhibit a time-varying complex network structure that emerges and self-organizes as a result of interactions with the environment. Network interactions optimize some intrinsic cost functions that are unknown and involve for…

   https://bioxfel.org/resources/2133

10. Abstract 13747: Targeting Urokinase-Type Plasminogen Activator (uPA) and the uPA Receptor, Reduces Vascular Inflammation and Lung Hemorrhage in Systemic Lupus and SARS CoV2 Infection in Mouse Models of Respiratory Distress Syndromes

    BioXFEL Publications 16 Dec 2021 Contributor(s): Brenda Hogue

    http://dx.doi.org/10.1161/circ.144.suppl_2.13747 Introduction: Acute respiratory distress syndromes with vascular inflammation and alveolar hemorrhage have high mortality and limited treatment. Autoimmune disease and severe viral infection cause vascular inflammation and hemorrhage. Serine protease coagulation pathways…

    https://bioxfel.org/resources/2130

11. PAL-XFEL Call for Proposals

    Events 5 Sep 2021

    Sep 05 2021

    PAL-XFEL Call for R&D beamtime Proposals Information for R&D beamtimePAL-XFEL operates the R&D beamtime program independent from general user beamtime. It is opened for the experiments that meet the following criteria. Establishing new experimental techniques or instruments at PAL-XFEL Proving critical performance of PAL-XFEL New users…

    https://bioxfel.org/events/details/1262

12. Exploring Structural Database Use in Crystallography: Workshop Series

    Events 21 Mar 2022

    Mar 21 2022

    US National Committee for Crystallography   Exploring Structural Database Use in Crystallography: Workshop Series The U.S. National Committee for Crystallography (USNC/Cr) of the National Academies of Sciences, Engineering, and Medicine is providing an online workshop series for students and researchers on the use, development, and maintenance of…

    https://bioxfel.org/events/details/1269

13. Phase Retrieval Workshop

    Events 18 Oct 2021

    Oct 18 2021

    BioXFEL is sponsoring a remote Phase Retrieval Workshop Monday, October 18 through Tuesday, October 19 2021.… Please fill in the form below to register. A Zoom meeting access code will be emailed out before the start of the meeting.This is a two-day online event delivered to an international audience. On the first day we will…

    https://bioxfel.org/events/details/1263

14. PDB50 Protein Data Bank Symposium

    Events 4 May 2021

    May 04 2021

    A special symposium celebrating the 50th anniversary of the Protein Data Bank May 4–5, 2021

    https://bioxfel.org/events/details/1254

15. 8th BioXFEL International Conference

    Events 2 Feb 2021

    Feb 02 2021

    The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its eighth annual international conference virtually February 2-4, 2021.

    https://bioxfel.org/events/details/1244