Biological function investigated by time-resolved structure determination

By Marius Schmidt

University of Wisconsin - Milwaukee

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Type

journal-article

Author

Marius Schmidt

Citation

Schmidt, M. (2023). Biological function investigated by time-resolved structure determination. Structural Dynamics, 10(1), 010901. https://doi.org/10.1063/4.0000177

Abstract

Inspired by recent progress in time-resolved x-ray crystallography and the adoption of time-resolution by cryo-electronmicroscopy, this article enumerates several approaches developed to become bigger/smaller, faster, and better to gain new insight into the molecular mechanisms of life. This is illustrated by examples where chemical and physical stimuli spawn biological responses on various length and time-scales, from fractions of Ångströms to micro-meters and from femtoseconds to hours.

DOI

Funding

NSF-STC Biology with X-ray Lasers (NSF-1231306)