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Polymer-based microfluidic device for on-chip counter-diffusive crystallization and <i>in situ</i> X-ray crystallography at room temperature

By Sarthak Saha, Can Özden, Alfred Samkutty, Silvia Russi, Aina Cohen, Margaret M. Stratton, Sarah Perry1

1. University of Massachusetts Amherst

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Category

BioXFEL Publications

Published on

Type

journal-article

Author

Sarthak Saha and Can Özden and Alfred Samkutty and Silvia Russi and Aina Cohen and Margaret M. Stratton and Sarah L. Perry

Citation

Saha, S., Özden, C., Samkutty, A., Russi, S., Cohen, A., Stratton, M. M., & Perry, S. L. (2023). Polymer-based microfluidic device for on-chip counter-diffusive crystallization and in situ X-ray crystallography at room temperature. Lab on a Chip, 23(8), 2075–2090. https://doi.org/10.1039/d2lc01194h

Abstract

Here we have reported novel polymeric devices to control fluid flow using surface forces and capillary action to facilitate counter-diffusive, on-chip protein crystallization.

DOI

http://dx.doi.org/10.1039/d2lc01194h

Funding

NSF-STC Biology with X-ray Lasers (NSF-1231306)