About the Group
Dr. Stroud focuses upon understanding function at the atomic level, and at the levels of macromolecular organization. He has a major commitment to understanding the structure and function of classes of integral membrane proteins. In enzymology, he focused on the structural basis for mechanisms, and on discovery of new principles for drug discovery aimed at enzymes and proteins. These include trypsin and serine proteases, thymidylate synthase, HIV protease, and HIV integrase. He currently studies specificity and mechanism of enzymes that modify RNA, particularly pseudo-uridine synthases, and RNA methylases. He also works with Peter Walter on the process of recognition of unfolded proteins inside the endoplasmic reticulum via the unfolded protein response, and the method of targeting membrane proteins to and through the translocating pore in the membrane. Dr. Stroud’s lab, as part of the BioXFEL Center will focus its research effort in the structure of membrane proteins, particularly channels. Dr. Stroud’s Lab has solved fundamental structural relationships related to ammonia and glycerol channels. The capacity to use nanocrystals in the future will dramatically increase productivity at the Center and for the Stroud lab.
