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De novo protein crystal structure determination from X-ray free-electron laser data

08 Jan 2014 | Publications | Contributor(s): K. Nass, S. Botha, G. J. Williams, T. R. Barends, J. E. Koglin, R. L. Shoeman, L. Foucar, S. Boutet, I. Schlichting, R. B. Doak, Mark Messerschmidt

The determination of protein crystal structures is hampered by the need for macroscopic crystals. X-ray free-electron lasers (FELs) provide extremely intense pulses of femtosecond duration, which …

https://bioxfel.org/resources/238

Protein structural ensembles are revealed by redefining X-ray electron density noise

06 Jan 2014 | Publications | Contributor(s): T. Alber, J. S. Fraser, P. T. Lang, James Holton

To increase the power of X-ray crystallography to determine not only the structures but also the motions of biomolecules, we developed methods to address two classic crystallographic problems: …

https://bioxfel.org/resources/282

Crystallographic data processing for free-electron laser sources

30 Jun 2013 | Publications | Contributor(s): A. Barty, R. A. Kirian, N. A. Zatsepin, F. Stellato, T. A. White, Henry Chapman, James Holton

A processing pipeline for diffraction data acquired using the `serial crystallography' methodology with a free-electron laser source is described with reference to the crystallographic analysis suite …

https://bioxfel.org/resources/236

Simultaneous femtosecond X-ray spectroscopy and diffraction of photosystem II at room temperature

25 Apr 2013 | Publications | Contributor(s): G. J. Williams, S. Gul, A. Zouni, P. H. Zwart, J. Yano, A. Lampe, N. K. Sauter, J. Kern, W. E. White, D. Sokaras, R. W. Grosse-Kunstleve, J. E. Koglin, T. C. Weng, C. Glockner, R. G. Sierra, M. J. Latimer, G. Han, S. Boutet, A. R. Fry, P. Glatzel, J. Sellberg, N. Echols, J. Hellmich, V. K. Yach, D. Milathianaki, R. Tran, H. Laksmono, S. Koroidov, B. Lassalle-Kaiser, R. Alonso-Mori, M. J. Bogan, A. Miahnahri, P. D. Adams, J. Messinger, D. W. Schafer, M. M. Seibert, J. Hattne, U. Bergmann, D. Difiore, R. J. Gildea, Mark Messerschmidt, Ranga Setlur

Intense femtosecond x-ray pulses produced at the Linac Coherent Light Source (LCLS) were used for simultaneous x-ray diffraction (XRD) and x-ray emission spectroscopy (XES) of microcrystals of …

https://bioxfel.org/resources/293

Crystallography: Sources of inspiration

31 Dec 2012 | Publications | Contributor(s): S. McSweeney, Petra Fromme

2014.

https://bioxfel.org/resources/237

Single mimivirus particles intercepted and imaged with an X-ray laser

02 Feb 2011 | Publications | Contributor(s): T. Gorkhover, D. Pietschner, S. Herrmann, C. Abergel, R. Andritschke, A. Homke, J. D. Bozek, L. Lomb, H. Gorke, O. Jonsson, F. Krasniqi, M. M. Seibert, R. L. Shoeman, B. Iwan, A. A. Miahnahri, C. Y. Hampton, G. Schaller, J. Ullrich, M. Hantke, I. Andersson, K. U. Kuhnel, A. Rocker, V. Seltzer, D. Rupp, S. Schorb, C. Caleman, R. G. Sierra, F. Schopper, J. Krzywinski, M. Adolph, H. Hirsemann, T. Ekeberg, D. P. DePonte, S. Boutet, B. Rudek, A. Barty, J. Andreasson, L. Gumprecht, G. Williams, N. Kimmel, D. Westphal, M. Liang, R. Kirian, B. Erk, S. W. Epp, C. Reich, G. Potdevin, J. Schulz, M. Bott, K. O. Hodgson, D. Rolles, S. Marchesini, C. Bostedt, R. B. Doak, A. Martin, J. Hajdu, L. Struder, H. Graafsma, P. Holl, F. R. Maia, M. Svenda, T. A. White, D. Odic, S. Bajt, B. Nilsson, A. Aquila, I. Schlichting, L. Foucar, G. Weidenspointner, N. Coppola, M. J. Bogan, R. Hartmann, A. Rudenko, D. Starodub, S. Stern, C. D. Schroter, G. Hauser, J. M. Claverie, M. Barthelmess, H. Soltau, Henry Chapman, Matthias Frank, Petra Fromme, Stefan Hau-Riege, Mark S. Hunter, Mark Messerschmidt, Marius Schmidt, John Spence, Uwe Weierstall

X-ray lasers offer new capabilities in understanding the structure of biological systems, complex materials and matter under extreme conditions. Very short and extremely bright, coherent X-ray …

https://bioxfel.org/resources/294

Reconstruction from a single diffraction pattern of azimuthally projected electron density of molecules aligned parallel to a single axis

31 Dec 2009 | Publications | Contributor(s): V. L. Shneerson, D. Starodub, Dilano Saldin, John Spence

Diffraction from the individual molecules of a molecular beam, aligned parallel to a single axis by a strong electric field or other means, has been proposed as a means of structure determination of …

https://bioxfel.org/resources/286