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Results (page 4 of 4)
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BioXFEL Publications 22 Sep 2017 Contributor(s): John Spence, Brenda Hogue, haiguang liu
http://dx.doi.org/10.1107/s2052252517012398 X-ray free-electron lasers (XFELs) provide new opportunities for structure determination of biomolecules, viruses and nanomaterials.… Using XFELs, it is possible to collect scattering information from single particles at high resolution, however particle heterogeneity and unknown…
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Batch crystallization of rhodopsin for structural dynamics using an X-ray free-electron laser
BioXFEL Publications 26 Jun 2015 Contributor(s): Garrett Charles Nelson, Gebhard F.X. Schertler
Rhodopsin is a membrane protein from the G protein-coupled receptor family. Together with its ligand retinal, it forms the visual pigment responsible for night vision. In order to perform ultrafast dynamics studies, a time-resolved serial femtosecond crystallography method is required owing to the nonreversible activation of…
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Sample deposition onto cryo-EM grids: from sprays to jets and back
BioXFEL Publications 25 Mar 2020 Contributor(s): Diana Monteiro, Martin Trebbin
http://dx.doi.org/10.1107/s2059798320002958 Despite the great strides made in the field of single-particle cryogenic electron microscopy (cryo-EM) in microscope design, direct electron detectors and new processing suites, the area of sample preparation is still far from ideal.… However, this approach is flawed since the blotting…
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Opportunities 13 Mar 2020
DESY is one of the world’s leading research centres for photon science, particle and astroparticle physics as well as accelerator physics.… We offer an open, inclusive, and international environment with first-class facilities. We are located on a vibrant research campus together with the University of Hamburg Centre for…
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OnDA: online data analysis and feedback for serial X-ray imaging
BioXFEL Publications 24 May 2016 Contributor(s): Henry Chapman
This article describes a free and open-source data analysis utility designed for fast online feedback during serial X-ray diffraction and scattering experiments:OnDA(online data analysis).… These monitors are capable of providing the essential information required for quick decision making in the face of extreme rates of data…
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A peak-finding algorithm based on robust statistical analysis in serial crystallography
BioXFEL Publications 3 Nov 2017 Contributor(s): Marc Messerschmidt, Brian Abbey
http://dx.doi.org/10.1107/s1600576717014340 The recent development of serial crystallography at synchrotron and X-ray free-electron laser (XFEL) sources is producing crystallographic datasets of ever increasing volume.… Among the blocks which constitute the analysis pipeline, one major bottleneck is `peak finding', whose goal is…
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BioXFEL Publications 30 Dec 2020 Contributor(s): Israel Rodriguez, Arthur Tinoco
http://dx.doi.org/10.3390/biomimetics6010001 Drug development is a decades-long, multibillion dollar investment that often limits itself.… X-ray structural characterization approaches have catalyzed the drug discovery and design process.… Powder X-ray diffraction (PXRD) has provided a method to determine the…
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XFEL Resources for Researchers
Uncategorised 17 Apr 2017
LCLS Beam-time Schedules … BioXFEL Beamtime Archive
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SPIND: a reference-based auto-indexing algorithm for sparse serial crystallography data
BioXFEL Publications 10 Dec 2018 Contributor(s): Chufeng Li, Richard Kirian, John Spence, haiguang liu, Nadia Zatsepin
http://dx.doi.org/10.1107/s2052252518014951 SPIND (sparse-pattern indexing) is an auto-indexing algorithm for sparse snapshot diffraction patterns (`stills') that requires the positions of only five Bragg peaks in a single pattern, when provided with unit-cell parameters.… E64, o1286], which is challenging for…
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Ligand binding remodels protein side-chain conformational heterogeneity
BioXFEL Publications 21 Mar 2022 Contributor(s): James Fraser
http://dx.doi.org/10.7554/elife.74114 While protein conformational heterogeneity plays an important role in many aspects of biological function, including ligand binding, its impact has been difficult to quantify. Macromolecular X-ray diffraction is commonly interpreted with a static structure, but it can provide information on both the anharmonic…
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Researchers Develop New Way To See Proteins In Motion
News 10 Jan 2017
A new imaging technique to see proteins live in motion has been developed.… Given that subtle motions govern protein functions that take place on nano time scales of trillionths of a second, the study offers great potential in knowing how proteins work.… The study's senior author was Rama Ranganathan,…
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BioXFEL Publications 15 Oct 2020 Contributor(s): Mark S. Hunter, Uwe Weierstall, Vadim Cherezov, Wei Liu
http://dx.doi.org/10.1107/s2052252520012701 Serial femtosecond crystallography (SFX) with X-ray free-electron lasers (XFELs) has proven highly successful for structure determination of challenging membrane proteins crystallized in lipidic cubic phase; however, like most techniques, it has limitations.… Using an optimized SFX…
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Sarah Perry (UMass Amherst) at HWI: Microfluidics at Room Temperature Crystallography
Events 19 Apr 2018
Apr 19 2018
Sarah L. Perry received BS degrees in Chemical Engineering and Chemistry from the University of Arizona, as well as a MS in Chemical Engineering working on gas phase methods for chemically passivating silicon surfaces for semiconductor manufacturing.… Paul J.A. Kenis. She began working as a postdoc for Prof. Matthew Tirrell in…
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Downloads 27 May 2015 Contributor(s): Nadia Zatsepin, Erin Uppington
BioXFEL has been involved in more than 150 XFEL experimental beamtimes.… Most experiments have been performed at LCLS in California, the world's first hard X-ray free electron laser, but the opening of new facilities such as SACLA in Japan, the European XFEL in Germany, PAL XFEL in Korea, and others around the world have enabled…
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Downloads 4 Jun 2014 Contributor(s): Jill Szczesek
BioXFEL will create a diverse and inclusive community of scholars who will transform our ability tovisualize the building blocks of life at a molecular scale, advancing from today's static pictures torecording detailed motions.… movies" will lead to deeper understanding and to the improvement… of the quality of…
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XFEL structure of melatonin receptor aids discovery of potential sleep disorder drugs
News 2 Mar 2020
A recent study published in Nature involving a multi-institutional collaboration with BioXFEL researchers has produced novel drug candidates that may help with various sleep disorders.… Melatonin discovery may help adjust biological clock Article originally published at UB News. Read original article here. Like breathing or…
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BioXFEL researchers make major advances in determination of gestational age
News 23 Jun 2020
An international group of researchers led by data scientists at the University of Wisconsin-Milwaukee have applied a machine learning technique they developed to substantially reduce the uncertainty in gestational age estimation.… Knowing the gestational age of a baby is key for optimal pregnancy management and in order to know…
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Hao Hu - BioXFEL Beamline Scientist
News 8 Aug 2019
After completing a Masters degree in Biomaterials at Sichuan University, China in 2013 and a Masters degree in Biomedical Engineering at ASU in 2016, Hao Hu joined the Spence & Weierstall lab at ASU to develop microfluidics devices for sample delivery.… She has been working primarily on viscous injectors, supporting many…
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Single-shot determination of focused FEL wave fields using iterative phase retrieval
News 3 Aug 2017
BioXFEL scientist Marc Messerschmidt, along with his colleagues, published a research article in OSA publishing. Summary: Determining fluctuations in focus properties is essential for many experiments at Self-Amplified-Spontaneous-Emission (SASE) based Free-Electron-Lasers (FELs), in particular for imaging single non-crystalline biological…
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BioXFEL Publications 10 Sep 2016 Contributor(s): Brian Abbey, Marc Messerschmidt
http://dx.doi.org/10.1126/sciadv.1601186 Brian Abbey and Ruben A. Dilanian and Connie Darmanin and Rebecca A. Ryan and Corey T. Putkunz and Andrew V. Martin and David Wood and Victor Streltsov and Michael W. M. Jones and Naylyn Gaffney and Felix Hofmann and Garth J. Williams and Sébastien Boutet and Marc Messerschmidt and M. Marvin Seibert and…
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Legal 25 Mar 2010
THE WORK (AS DEFINED BELOW) IS PROVIDED UNDER THE TERMS OF THIS LICENSE.… ANY USE OF THE WORK OTHER THAN AS AUTHORIZED UNDER THIS LICENSE OR COPYRIGHT LAW IS PROHIBITED.… ACCEPTS AND AGREES TO BE BOUND BY THE TERMS OF THIS LICENSE. THE LICENSOR (YOU) GRANTS THE RIGHTS CONTAINED HERE IN CONSIDERATION…
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Biography 21 May 2013
Matthias Frank Advanced Diagnostics and Instrumentation Group Leader Lawrence Livermore National Laboratory Physical & Life Sciences Directorate Physics Division 7000 East Avenue, Mail Stop L-211 Livermore, CA 94551, USA frank1@llnl.… Dr. Matthias Frank is the group leader of the Advanced Diagnostics and Instrumentation Group…
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Rapid sample delivery for megahertz serial crystallography at X-ray FELs
BioXFEL Publications 27 Jul 2018 Contributor(s): Max Oliver Wiedorn, Joe Chen, Jesse David Coe, Rita Graceffa, Brenda Hogue, Petra Fromme, Richard Kirian, Henry Chapman
http://dx.doi.org/10.1107/s2052252518008369 Liquid microjets are a common means of delivering protein crystals to the focus of X-ray free-electron lasers (FELs) for serial femtosecond crystallography measurements.… With the advent of X-ray FELs with megahertz rates, the typical velocities of these jets must be increased…
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Protein Production and Purification at UPR-RP
Events 16 Feb 2018
Feb 16 2018
BioXFEL Protein Production and Purification Workshop The NSF BioXFEL Science and Technology Center will be sponsoring a workshop on March 16th, 2018 for all interested UPR researchers. The full day course will cover the basics of the biochemistry, cloning, expression and purification of proteins. We will discuss the theory behind common…
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9th Annual BioXFEL International Conference
Events 8 Feb 2022
Feb 08 2022
The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its ninth annual international conference virtually February 8-10, 2022. Our annual External Advisors Meeting will be held Monday, Feb 7, 2022. The annual International BioXFEL Conference brings together experts in a variety of…
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European XFEL Virtual User Information Meeting - 7th Call for Proposals
News 19 Nov 2020
European XFEL Virtual User Information Meeting - 7th Call for Proposals A virtual information meeting will be hosted by the European XFEL User Organization Executive Committee (UOEC) and held on 25 November 2020 17:30-19:30 (Hamburg/Schenefeld local time - CET) … The event will specifically address our 7th Call…
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2014 Two Day Workshop on Bio-XFEL Data Analysis
Events 21 Aug 2014
Aug 21 2014
Sponsored by: Click here to view the workshop tutorials 2014 Data Analysis Workshop We are pleased to announce the first Workshop on Bio-XFEL Data Analysis, organized as a collaborative effort between the NSF BioXFEL Science and Technology Center, the Physical Biosciences Division of Lawrence Berkeley National Laboratory and SLAC…
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BioXFEL researchers publish first melatonin receptor structures
News 8 May 2019
An international team, including BioXFEL researchers, used an X-ray laser at the Department of Energy’s SLAC National Accelerator Laboratory to create the first detailed maps of two melatonin receptors that tell our bodies when to go to sleep or wake up, and guide other biological processes.… A better understanding of how they…
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Protein Production and Purification Workshop at UPR-Mayaguez
Education 19 Apr 2016
BioXFEL Protein Production and Purification Workshop The BioXFEL Science and Technology Center will be sponsoring a 1-day event on May 11th, 2016 for all interested UPR researchers. The full day course will cover the basics of the biochemistry, cloning, expression and purification of proteins. We will discuss the theory behind common techniques,…
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Biography 21 May 2013
Alexandra RosAsst Professor Chemistry & Biochemistry Arizona State University PO Box 871604 Tempe, AZ 85287 alexandra.ros@asu.edu(480) 965 5323 Dr. Ros received her PhD in Chemistry from the Swiss Federal Institute of Technology in Lausanne (EPFL, Switzerland) in 2000, where she started developing methods for protein analysis.……
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U.S. Crystal Growing Competition celebrates 5th anniversary
News 3 Oct 2018
The contest — founded by a UB chemist — reaches thousands of children around the country each year … In 2014, University at Buffalo crystallographer Jason Benedict had an idea: What better way to share his love of science and crystals than to start a nationwide contest in which kids can grow their own?… This…
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BioXFEL ASU team among first user groups at Europe’s brightest light source
News 31 Oct 2017
A team of BioXFEL ASU scientists led by Professor and STC Member Alexandra Ros in the School of Molecular Sciences and the Biodesign Center for Applied Structural Discovery, has been just the second user group to conduct experiments at the brand new European X-ray free electron laser facility (EuXFEL) in Hamburg, Germany.……
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Events 5 Sep 2021
Sep 05 2021
PAL-XFEL Call for R&D beamtime Proposals … Information for R&D beamtimePAL-XFEL operates the R&D beamtime program independent from general user beamtime.… Establishing new experimental techniques or instruments at PAL-XFEL Proving critical performance of PAL-XFEL New users with no experience in XFEL…
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Biography 21 May 2013
Petra Fromme Arizona State University Department of Chemistry and Biochemistry P.… Box 871504 Tempe, AZ 85287-1504 pfromme@asu.edu (480) 965-9028With over 20 years of experience in the field of membrane protein X-ray crystallography, Dr. Fromme's expertise lies in fs crystallography and developmental methodology for the…
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Series 21 Jul 2015 Contributor(s): Nadia Zatsepin
During your beamtime … 1. Before your first non-DARK run: Occasionally, some data are not recorded by accident (such as detector distance).… At the start of the shift, confirm with the beamline scientist that those data are selected for recording in the DAQ. Soon after the first data are recorded, confirm…
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Legal 25 Mar 2010
What is Creative Commons? The Creative Commons (CC) enables copyright holders to grant some or all of their rights to the public while retaining others through a variety of licensing and contract schemes.… 0 license, which is well suited to education and academic research.… Offering your work under a CC license…
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Introduction to serial femtosecond crystallography data analysis
Series 21 Jul 2015 Contributor(s): Nadia Zatsepin, Tom Grant
Click or use the left and right arrow keys to advance forward and backward in this embedded presentation (downloadable PDF available in the Supporting Docs tab above) … Serial femtosecond crystallography with X-ray free electron lasers X-ray free electron lasers (XFELs) have enabled biomolecular nano- and micro-crystallography at…
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Downloads 20 Dec 2016
All Schedules on LCLS Website LCLS Run 15 Schedule (June 2017 - Nov 2017) LCLS Run 14 Schedule (Aug 2016 - Dec 2016) LCLS Run 13 Schedule (Mar 2016 - Aug 2016)LCLS Run 12 Schedule (Oct 2015 - Mar 2016)LCLS Run 11 Schedule (Mar 2015 - Aug 2015)LCLS Run 10 Schedule (Oct 2014 - Mar 2015)
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Biography 21 May 2013
Eaton (Ed) LattmanDepartment of Structural BiologySUNY BuffaloHauptman-Woodward Medical Research Institute700 Ellicott Street, Buffalo, NY 14203lattman3@gmail.… Ed Lattman joined the University at Buffalo (UB), Department of Structural Biology as a faculty member, and Hauptman Woodward Medical Research Institute (HWI) as its Chief…
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10th Annual BioXFEL International Conference
Events 16 May 2023
May 16 2023
Click here for Conference Agenda Click here for Welcome Packet The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its 10th Annual International Conference May 16 - 18, 2023. The "From Time-Resolved Structure Factor Amplitudes to Structure and Dynamics"… …
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Project Management Master Certification
Events 25 Jul 2017
Jul 25 2017
The Project Management Master Certification course will be offered July 25-28, 2017 at Arizona State University in Phoenix, Arizona. Project management professionals, business and technology professionals, students, and educators are invited to register at the Project Management Academy USA website.… July 25-28,…
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DOE Early Career Research Award
Events 1 Jan 2019
Jan 01 2019
Department of Energy Announces Early Career Research Program for FY 2019 … Awards Will Support University and National Laboratory Scientists WASHINGTON, D.C. — The U.S. Department of Energy (DOE) announced today it is accepting proposals for the tenth year of the DOE Office of Science Early Career Research Program to…
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Filming Antibiotic Resistance in Slow-Motion
News 13 Sep 2021
Using the X-ray laser European XFEL an international team of researchers has successfully filmed a reaction step that is important for the development of antibiotic resistance.… The molecular film captures the very rapid reaction of the enzyme beta-lactamase from tuberculosis bacteria with the cephalosporin antibiotic ceftriaxone…
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BioXFEL Publications 14 Apr 2021 Contributor(s): Iris Diane Young, James Holton, Michael Thompson, James Fraser, Ron Morganti
http://dx.doi.org/10.1126/sciadv.abf8711 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate–ribosylation signaling.… Here, we report a massive crystallographic screening and computational docking effort,…
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NSF BioXFEL STC Postdoctoral Research Award granted to Benjamin Stauch and Ahmad Hosseinizadeh
News 30 Mar 2017
The BioXFEL Center is proud to announce the recipients of the Postdoctoral Research Award, Benjamin Stauch and Ahmad Hosseinizadeh.… Stauch is a Postdoctoral Research Associate in the group of Prof. Vadim Cherezov at the Bridge Institute of the University of Southern California in Los Angeles. He received his Master’s degree…
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Uncategorised 20 Oct 2021
The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its ninth annual international conference virtually February 8-10, 2021. Our annual External Advisors Meeting will be held Monday, Feb 7, 2021. The annual International BioXFEL Conference brings together experts in a variety of…
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David Case (Rutgers) at HWI: CANCELLED
Events 22 Mar 2018
Mar 22 2018
THIS TALK HAS BEEN CANCELLED DUE TO HAZARDOUS WEATHER AND TRAVEL CONDITIONS. WE ARE IN THE PROCESS OF RESCHEDULING. Dr. David Case is a distinguished professor at Rutgers University. His research consists of the theoretical chemistry of biomolecules. Particular areas of interest include molecular dynamics simulations of proteins and…
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Series 21 Jul 2015 Contributor(s): Nadia Zatsepin
Before your beamtime … 1. Get an account in the LCLS system. You need a SLAC user portal account (you must be listed as a collaborator on a proposal to get one), and you also need a unix account. Follow the instructions here: https://confluence.slac.stanford.edu/display/PCDS/Accounts Make sure your SLAC Cyber Security…
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BioXFEL research published in Nature Methods enables seeing inside particles in solution
News 29 Jan 2018
New research published today in Nature Methods by BioXFEL researcher Tom Grant opens up new avenues for studying the structures of particles floating in solution. Typically, molecular structures are determined using a technique known as crystallography, where molecules are chemically induced to align next to each other in a large 3D…
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Biography 21 May 2013
Abbas Ourmazd University of Wisconsin-Milwaukee Department of Physics 1900 East Kenwood Boulevard Milwaukee, WI 53211 ourmazd@uwm.… Abbas Ourmazd, Ph.D., is currently Distinguished Professor of Physics and Electrical Engineering at the University of Wisconsin-Milwaukee. His current interests include the structure of biological…
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BioXFEL NSF Graduate Research Fellowship Proposal Writing Workshop
Events 25 May 2017
May 25 2017
BioXFEL will be holding a NSF Graduate Research Fellowship Program (NSF GRFP) Proposal Writing Workshop after our NSF site visit on May 25th, 2017. It is our hope that this workshop will give our students essential training in proposal writing and enhance their chances of receiving an NSF Fellowship Award.… This will…
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XFELs Open A New Era in Structural Chemical Biology
News 22 Jun 2017
X-ray crystallography, the workhorse of structural biology, has been revolutionized by the advent of serial femtosecond crystallography using X-ray free electron lasers. Here, the fast pace and history of discoveries are discussed together with current challenges and the method's great potential to make new structural discoveries, such as the…
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Education 9 Sep 2016
Research Opportunities for UNLV Students … X-ray free electron lasers (XFELs) present unique capabilities that have the potential to revolutionize structural biology and its ability to probe the biological world. BioXFEL is a NSF Science and Technology Center that is focused on developing new techniques, educating the general…
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XFEL Crystal Blaster Educational Game
Knowledge Transfer 11 Apr 2017
BioXFEL member and undergraduate researcher, Fiacre Kabayiza, has created a game to help educate school-aged students on the topic of XFEL science.… Download for Free The XFEL game is available on the Apple App store, Google Play and here on our website. Download Windows Version: Download here Download Mac Version:…
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Scientific Leadership Development Program
Education 11 Oct 2018
This new initiative promotes the leadership of post-doctoral associates and senior graduate students by inviting them to develop educational content in their areas of expertise and interest.… This initiative has two components. 1. Leadership Participation - BioXFEL Scholars will participate in the planning and implementation of a…
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Education 29 Sep 2016
BioXFEL member and undergraduate researcher, Fiacre Kabayiza, has created a game to help educate school-aged students on the topic of XFEL science.… Download for Free The XFEL game is available on the Apple App store, Google Play and here on our website. Download Windows Version: Download here Download Mac Version:…
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News 5 Sep 2019
Some of the world’s most accomplished scientific minds will converge on Arizona State University’s Tempe campus on November 6, 7 and 8 to explore new methods that make it possible to observe molecules in action. Illustrating the adage, "seeing is believing," the conference, “Functional dynamics – visualizing molecules in action,” will…
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BioXFEL STC 4th Annual International Conference
Events 10 Jan 2017
Jan 10 2017
Sponsored in part by: Thank You for Your Attendance and Sponsorship of the 4th BioXFEL Conference and Single Particle Sample Delivery Workshop … We would like to thank you for your attendance of the SP Workshop and 4th Annual Conference. Specifically, we would like to thank our Program Chairs &…
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BioXFEL STC 3rd Annual International Conference
Events 13 Jan 2016
Jan 13 2016
REGISTRATION DEADLINE EXTENDED TO DECEMBER 18TH … The BioXFEL National Science Foundation Science and Technology Center is pleased to announce that it will be hosting its third annual international conference in San Juan, Puerto Rico January 13th - 15th, 2016. This segment of the series will focus on biological methods and…
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Scientific Communications Workshop
Education 4 Dec 2017
Every summer, BioXFEL leads a series of Communications Workshops concurrent with the summer internship program. Staff scientists Russell Fung (UWM), Bill Bauer (HWI) and Ganesh Subramanian (ASU) manage these workshops at their respective sites. The workshop is held bi-weekly and teaches our interns how to effectively organize and present…
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UWM researchers create first 3D movie of virus in action
News 14 Aug 2017
A research collaboration led by the University of Wisconsin-Milwaukee has for the first time created a three-dimensional movie showing a virus preparing to infect a healthy cell.… The research has the potential to fundamentally advance our understanding of how biological processes inside the cell work.… The feat…
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Undergraduate Students - Funding Opportunities
Education 11 Jul 2017
Public Databases for Fellowships/Scholarships Please click on the below links for access to various public databases that are affiliated with some the top colleges/universities in the nation: ~ Yale University ~ Cornell University ~ Stanford University ~ SPIN Database Undergraduate Scholarships and Fellowships ……
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Opportunities 9 Nov 2020
The Thompson Lab at University of California Merced is recruiting a Postdoctoral Scholar and a Junior Research Specialist. The Postdoc will work on projects related to multi-temperature and time-resolved (T-jump) crystallography at synchrotrons and XFELs.… ucmerced.edu/JPF01028 The Junior Specialist will support wet lab…
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News 10 Jan 2023
Click here for Conference Agenda Click here for Welcome Packet The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its 10th Annual International Conference May 16 - 18, 2023. The "From Time-Resolved Structure Factor Amplitudes to Structure and…
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BioXFEL Undergraduate Internships
Education 5 Nov 2013
BioXFEL is a National Science Foundation Science and Technology Center (STC) that focuses on promoting and advancing the study of Biological molecules using X-ray Free Electron Lasers (XFELs). A summer internship is the best way to get started in this new and exciting field. BioXFEL offers Summer Research Internships to highly qualified…
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BioXFEL NSF Graduate Research Fellowship Proposal Writing Workshop
Education 8 Feb 2017
BioXFEL will be holding a NSF Graduate Research Fellowship Program (NSF GRFP) Proposal Writing Workshop prior to our NSF site visit on May 22nd, 2017. It is our hope that this workshop will give our students essential training in proposal writing and enhance their chances of receiving an NSF Fellowship Award.… This will event…
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PDB50 Protein Data Bank Symposium
Events 4 May 2021
May 04 2021
A special symposium celebrating the 50th anniversary of the Protein Data Bank May 4–5, 2021 PDB50 will mark an important milestone in the history of structural biology. In 1971, the structural biology community established the single worldwide archive for macromolecular structure data — the Protein Data Bank (PDB).… PDB…
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Events 24 Sep 2019
Sep 24 2019
SSRL / LCLS 2019 Users Meeting September 24-27, 2019 SLAC National Accelerator LaboratoryMenlo Park, CA Full details here … The Stanford Synchrotron Radiation Lightsource (SSRL) and the Linac Coherent Light Source (LCLS) will host a joint users' meeting at SLAC National Accelerator Laboratroy on September 24-27, 2019.…
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EducationM 11 Jul 2017
BioXFEL is a National Science Foundation Science and Technology Center (STC) that focuses on promoting and advancing the study of Biological molecules using X-ray Free Electron Lasers (XFELs). A summer internship is the best way to get started in this new and exciting field. BioXFEL offers Summer Research Internships to highly qualified…
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News 25 Sep 2018
Srd Div. Director [Senior/ Distinguished Staff Scientist] Link to job posting Job Requisition #: 3370 Classification Title: Staff Scientist- Senior Location: Menlo Park, CA (HQ) # of openings: 1 Position Summary LCLS SCIENCE RESEARCH AND DEVELOPMENT (SRD) DIVISION LEADER: … The Linac Coherent Light Source (LCLS) is…
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Job opening - Post Doc in THz Biomolecular Optics at University at Buffalo
News 20 Feb 2018
DOE funded postdoc position for the study of photosynthesis proteins and enzymes using terahertz light.… The position involves instrumentation development, sample preparation and characterization.… PhD in experimental physics, biophysics, structural biology, chemistry or biochemistry Record of publications…
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Cheetah documentation - all keywords
Series 21 Jul 2015 Contributor(s): Nadia Zatsepin
The official Cheetah website is http://www.desy.… These pages will not reproduce all the content from the Cheetah site, but are meant as an addendum.… Complete listing of keywords for Cheetah's configuration files Many of these are power user settings designed for turning on or off features in…
https://bioxfel.org/resources/cheetah_documentation_keywords
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Opportunities 26 Oct 2021
Research. Enzyme function is potentially linked to the entire protein conformational space sampled by enzyme and enzyme-intermediate complexes during catalysis. Importantly, this holds for lowly populated conformational sub-spaces of higher free energy, which can differ distinctly from the lowest free energy conformational sub-space typically…
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Knowledge Transfer 11 Apr 2017
BioXFEL researchers are pioneering new methods of sample delivery, nano crystallization, and other technologies.… Gas dynamic virtual nozzle for generation of microscopic droplet streams A nozzle for producing a single-file stream of droplets of a fluid, methods using the nozzle, and an injector, comprising the nozzle of…
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Science 4 May 2021
The HWI Cryo-Electron Microscopy Center The Cryo-Electron Microscopy Center supports industry, academic, government, and non-profit research institutes, providing single-particle and microcrystal electron diffraction capabilities.… The Cryo-EM Center at HWI provides: … Expert staff – Dr. Qiu-Xing…
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Postdocs - Funding Opportunities
Education 12 Jul 2017
Institutional Public Databases for Fellowships/Funding Options ~ Michigan State University's Public Database ~ External fellowships and resources for graduate students - University of Illinois … ~ Fellowships for graduate students - Cornell University … ~ Fellowships opportunities for graduate students -…
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Education 17 Dec 2019
Important Information for the Participants of the Structural Biology with X-rays Workshop BioSAXS Practical Sessions Information General Information: This BioSAXS part of the workshop will be focusing on the introduction to solution X-ray scattering as a method to answer questions in current structural biology research. In addition to the…
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NSF awards $22.5 million to capture biology at the atomic level using X-ray lasers
News 26 Sep 2018
A research consortium led by the University at Buffalo has been awarded $22.… BioXFEL is revolutionizing bioimaging through collaborations with academia and industry, including Google Brain … By Ellen Goldbaum Original Article Here BioXFEL, an NSF Science and Technology Center and UB’s first such center,…
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Graduate Students - Funding Opportunities
Education 11 Jul 2017
Institutional Public Databases for Scholarships/Fellowships ~ Graduate Scholarships, Fellowships, and Loans at Michigan State University Michigan State University offers a range of funding options for graduate students.… ~ Fellowships for Graduate Students - Florida State University … Please note: "These…
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Education 25 Jun 2015
BioXFEL is dedicated to sharing resources to help engage students and researchers in activities within the Science and Technology Center.… These activities will be occurring throughout the year and are listed below. 1. BioXFEL STC Annual International Conference The BioXFEL National Science Foundation Science and…
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Series 21 Jul 2015 Contributor(s): Nadia Zatsepin
Accessing your data at LCLS The LCLS data analysis website is an excellent resource to help users do everything from setting up an account to analyzing their LCLS data with LCLS software. Our site is designed to help you with data analysis for serial femtosecond crystallography experiments at LCLS.… Please refer to the LCLS…
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5. Data reduction and hit finding
Series 21 Jul 2015 Contributor(s): Nadia Zatsepin, Richard A Kirian
Graphical Image Analysis at LCLS: Psocake New graphical image analysis software (Psocake) have been developed at LCLS by Chunhong Yoon.… Psocake enables you to deal with or run the following: … Diffraction Geometry ROI Histogram Small Data Peak Finder … Hit Finder ……
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Series 21 Jul 2015 Contributor(s): Nadia Zatsepin
The official Cheetah website is http://www.desy.… These pages will not reproduce all the content from the Cheetah site, but are meant as an addendum.… For a list of all Cheetah's keywords, click here. What is Cheetah? Cheetah is a set of programs for processing serial diffraction data data from at free…
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About 11 Sep 2013
Positions posted based on availability and relationship to the Center. To post your job opening here, please contact BioXFEL The RCSB Protein Data Bank at Rutgers University is looking to fill three new positions described below: … Scientific Software Developer (UCSD) … The RCSB PDB is seeking a Scientific…
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8th BioXFEL International Conference
Events 2 Feb 2021
Feb 02 2021
The National Science Foundation BioXFEL Science and Technology Center is pleased to announce that it will be hosting its eighth annual international conference virtually February 2-4, 2021. Our annual External Advisors Meeting will be held Monday, Feb 1, 2021. The annual International BioXFEL Conference brings together experts in a variety of…
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Earliest molecular events of vision revealed
News 23 Mar 2023
A large international team lead by Valerie Paneels and Gebhard Schertler revealed the molecular mechanism of light receptor activation in the eyes of vertebrae animals by time-resolved serial femtosecond crystallography (TR-SFX).… BioXFEL researchers Schmidt and Stojković were invited to write a News and Views article summarizing…
